The Song Of The Cell: An Exploration Of Medicine And The New Human

The Song Of The Cell: An Exploration Of Medicine And The New Human

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  • Type:Epub+TxT+PDF+Mobi
  • Create Date:2022-12-25 06:52:07
  • Update Date:2025-09-07
  • Status:finish
  • Author:Siddhartha Mukherjee
  • ISBN:067009272X
  • Environment:PC/Android/iPhone/iPad/Kindle

Summary

From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, about the transformation of medicine through our radical new ability to manipulate cells。 Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human。

Mukherjee begins this magnificent story in the late 1600s, when a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek looked down their handmade microscopes。 What they saw introduced a radical concept that swept through biology and medicine, touching virtually every aspect of the two sciences, and altering both forever。 It was the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units。 Our organs, our physiology, our selves—hearts, blood, brains—are built from these compartments。 Hooke christened them “cells”。

The discovery of cells—and the reframing of the human body as a cellular ecosystem—announced the birth of a new kind of medicine based on the therapeutic manipulations of cells。 A hip fracture, a cardiac arrest, Alzheimer’s dementia, AIDS, pneumonia, lung cancer, kidney failure, arthritis, COVID pneumonia—all could be re-conceived as the results of cells, or systems of cells, functioning abnormally。 And all could be perceived as loci of cellular therapies。

In The Song of the Cell, Mukherjee tells the story of how scientists discovered cells, began to understand them, and are now using that knowledge to create new humans。 He seduces listeners with writing so vivid, lucid, and suspenseful that complex science becomes thrilling。 Told in six parts, laced with Mukherjee’s own experience as a researcher, a doctor, and a prolific reader, The Song of the Cell is both panoramic and intimate—a masterpiece。

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Reviews

Eschargot

Absolutely fantastic book。 I need to go back and reread the other two as well :)。

Nick Byers

A very informative and interesting piece of work detailing the numerous cells that make us, us。 From the first discovery of their existence to the new ways they are being changed to combat disease this book covers it all。 I feel it walks the line of not holding the reader's hand too much but also not overloading the reader with too much high level medical jargon very well。 A very informative and interesting piece of work detailing the numerous cells that make us, us。 From the first discovery of their existence to the new ways they are being changed to combat disease this book covers it all。 I feel it walks the line of not holding the reader's hand too much but also not overloading the reader with too much high level medical jargon very well。 。。。more

James

3。5

Ismail Alhajj

Truly a magnificent song that will make you dance while reading

Neha

Typical of SM poetic style in explaining deep scientific content with a rich dose of historical account of medicine。

Karen Carlson

mentioned by https://post。news/weindl on Post - sounds very good, why didn't I notice this beofre/ mentioned by https://post。news/weindl on Post - sounds very good, why didn't I notice this beofre/ 。。。more

Mehdi

This book clearly and succinctly summarizes many normal and diseased states of our bodies。 We are also given a glimpse of some fascinating medical advances。 But the real magic is in the anecdotes and storytelling。

Kathy Jackson

This is not a quick read。 However, it is an excellent, informative, and well-written book on cellular biology that all can understand。 I recommend "The Emperor of all Maladies" to everyone, and this one is a close 2nd。 This is not a quick read。 However, it is an excellent, informative, and well-written book on cellular biology that all can understand。 I recommend "The Emperor of all Maladies" to everyone, and this one is a close 2nd。 。。。more

Sylvia

It started out promisingly but soon all narrative disappeared and it read like a biology text。 Way too scientific and boring for me。

Bruce

I was a lucky winner of this book on Goodreads。 Though it is sometimes a bit deep for the layman (me) I found the history of the field of cell biology intriguing and the story of the cell fascinating。 Nature is interesting inasmuch as all life begins from a single cell which then becomes more cells that eventually specialize。 Each of the six parts begins with a one page introduction to the ensuing chapters that further explain the type of cell being discussed。 The author intersperses personnel m I was a lucky winner of this book on Goodreads。 Though it is sometimes a bit deep for the layman (me) I found the history of the field of cell biology intriguing and the story of the cell fascinating。 Nature is interesting inasmuch as all life begins from a single cell which then becomes more cells that eventually specialize。 Each of the six parts begins with a one page introduction to the ensuing chapters that further explain the type of cell being discussed。 The author intersperses personnel memories of patients while explaining the development of medicine as related to cell biology。 While starting with the initial "discovery" of the cell, the author goes back in time to discusses various 'philosophies' regarding life and its origins。 He then goes on to describe 'types' of cells ending with acknowledging gaps in our understanding of the interconnectedness of cells and the 'songs' they sing。 。。。more

Silvano Paternoster

great book deserving 5 stars (maybe 4。5 but let's round it up to 5) very well written, it flows very well, and gives lots of detailed real life examples of what medicine has been doing since its birth centuries ago recommended to any person really。 From high school student to retirees。 Anyone can learn a lot from this book, including scientists that already have a background in the topic as myself great book deserving 5 stars (maybe 4。5 but let's round it up to 5) very well written, it flows very well, and gives lots of detailed real life examples of what medicine has been doing since its birth centuries ago recommended to any person really。 From high school student to retirees。 Anyone can learn a lot from this book, including scientists that already have a background in the topic as myself 。。。more

Hediyeh

I love all of Mukherjee’s books and this is no exception。 It did feel a bit less focused and more meandering than his others but still worth the read。

Karen Grove Trimmer

Didn’t quite finish this one。 I found the history early on more interesting than the biology later on。

Wanda

This was almost like reading two completely different books。 The first, made up of the book's first three sections, was a history of the early scientific research and resulting discoveries about the cell and an overview of cellular functions。 The writing was as dry and as dense as a textbook。 If I hadn’t read Immune recently and had some familiarity with the terminology, I don’t think I could have understood what little I did。 The second, starting with the section about the pandemic through to This was almost like reading two completely different books。 The first, made up of the book's first three sections, was a history of the early scientific research and resulting discoveries about the cell and an overview of cellular functions。 The writing was as dry and as dense as a textbook。 If I hadn’t read Immune recently and had some familiarity with the terminology, I don’t think I could have understood what little I did。 The second, starting with the section about the pandemic through to the end, was more like what I’ve come to expect from this author – eloquent writing and enough examples and case histories to make the science accessible to lay readers like myself。 If I read this again I’ll definitely start with the second half。 And I hope what the author hinted at comes true – an updated version of his prize winning book The Emperor of All Maladies。 I’ll be reading it for a third time if that happens。 3½ stars 。。。more

Daniel Farabaugh

This was an enjoyable read but not as good as his earlier works。 It lacked the focus of his earlier works and the different types of cells blended together at times。 His writing is strong and he does a good job of bringing in the historical figures who played a significant role。

Jeffrey (Akiva) Savett

Another very strong work by Mukherjee!This trilogy, beginning with The Emperor of All Maladies, The Gene, and now, The Song of the Cell is a monumental gift from Mukherjee to lay readers interested in medical history, biology, virology, and heredity。That is not to suggest that any of these are “easy” reads or feel dumbed down。 The latest volume is, by far, the shortest of the trilogy, but it feels just right。 It’s also inspiring。 As someone who defines “God” Spinoziscally, a book celebrating the Another very strong work by Mukherjee!This trilogy, beginning with The Emperor of All Maladies, The Gene, and now, The Song of the Cell is a monumental gift from Mukherjee to lay readers interested in medical history, biology, virology, and heredity。That is not to suggest that any of these are “easy” reads or feel dumbed down。 The latest volume is, by far, the shortest of the trilogy, but it feels just right。 It’s also inspiring。 As someone who defines “God” Spinoziscally, a book celebrating the “song” about the very STUFF that literally unites all living things is always welcome。 。。。more

M

Recommend if you have some science/medical background I was fascinated by Siddhartha Mukherjee’s “Emperor of All Maladies,” but “The Gene” needed less familial history and sociology。 This cell biology textbook gives less of an overview, and Mukherjee concentrates more on the science, including cellular physiology and pathology; current biomedical research; genetic engineering and editing; recent tech advances; new trends and treatments。 I liked the chapters on stem cells, IVF, gene therapy, COVI Recommend if you have some science/medical background I was fascinated by Siddhartha Mukherjee’s “Emperor of All Maladies,” but “The Gene” needed less familial history and sociology。 This cell biology textbook gives less of an overview, and Mukherjee concentrates more on the science, including cellular physiology and pathology; current biomedical research; genetic engineering and editing; recent tech advances; new trends and treatments。 I liked the chapters on stem cells, IVF, gene therapy, COVID-19, and especially the deep dive into cancer cells。The audiobook narrator is very good, but it took me a while to adjust to a non-SouthAsian narrator。 。。。more

Tiffany

Excellent and easy to understand book about the building blocks of human life。 One of my favorite topics!

Jenn Adams

This felt like if you made a textbook genuinely approachable and accessible。 Some of this I knew, some of this I wanted to know, and some of this I could probably review one more time to really absorb it。 Would definitely recommend。I had tried this author's The Gene and couldn't get into it; I still look forward to getting to The Emperor of All Maladies at some point, though I do worry that we have probably learned a lot in the 12 years since it has been published。 This felt like if you made a textbook genuinely approachable and accessible。 Some of this I knew, some of this I wanted to know, and some of this I could probably review one more time to really absorb it。 Would definitely recommend。I had tried this author's The Gene and couldn't get into it; I still look forward to getting to The Emperor of All Maladies at some point, though I do worry that we have probably learned a lot in the 12 years since it has been published。 。。。more

Caitlin Cosgrove

Another absolutely brilliant book by Mukherjee

Laavanya

I could not get past page 105。 Though well written, it was so dry that it did not keep me engaged enough。

Steve

Another engrossing book about human biology from Siddhartha Mukherjee。 Not really an ELI5 level, but still quite accessible。 Interesting historical background on important discoveries in cellular biology, as well as modern trends and developments in the field。 Strongly recommended for anyone who is not already a PhD。

Alexa

Another great book from Mukherjee, although it still doesn't top Emperor of All Maladies for me。 Mukherjee has an amazing talent for writing about science in a way that is digestible for someone without expertise in this area but also in a deeply lyrical and moving way, interspersing metaphors and anecdotes throughout that make this read nothing like a textbook while also educating at the same time。 His awe and curiosity for the subject radiate off the page and make the reader feel the same。 I l Another great book from Mukherjee, although it still doesn't top Emperor of All Maladies for me。 Mukherjee has an amazing talent for writing about science in a way that is digestible for someone without expertise in this area but also in a deeply lyrical and moving way, interspersing metaphors and anecdotes throughout that make this read nothing like a textbook while also educating at the same time。 His awe and curiosity for the subject radiate off the page and make the reader feel the same。 I look forward to whatever he does next。 。。。more

Brian Campbell

Brilliant writing that laid down some basic concepts and terms then built slowly to a description of many types of cells including very well done descriptions of both anatomy and physiology。 E。g。, over the last 5 years, I perused a few articles from a science email feed, maybe getting lost in finer points of advancements in CAR T-cell therapy。 This text explained the T-cell, then how it often fails to bind to a cancer cell and finally how changing genes in a patient’s T-cells produce the CAR T-c Brilliant writing that laid down some basic concepts and terms then built slowly to a description of many types of cells including very well done descriptions of both anatomy and physiology。 E。g。, over the last 5 years, I perused a few articles from a science email feed, maybe getting lost in finer points of advancements in CAR T-cell therapy。 This text explained the T-cell, then how it often fails to bind to a cancer cell and finally how changing genes in a patient’s T-cells produce the CAR T-cell that fulfills its function as a member of the immune system and kills the cancer cell。 I like how many of the chapters start with the history of discoveries about the cell and continue to status of knowledge in 2021。 The chapter on the COVID pandemic brought humility to the story of scientific progress as did the chapter on cancer cells。 The epilogue brought up genetic engineering on humans。 I really enjoyed the scientist’s perspective in this text。 Pride in the advancements along with a restless desire to find out more to reduce the frustration of being unable to help patients heal。 Some scientific advancements are so successfully commercialized (e。g。, cell phones) that the cost of ongoing science advancements are a small burden on the income of the industry。 Not cell biology in medicine where the needs are so critical and so varied。 I’ll be looking for more of Mukherjee’s titles at the library。 。。。more

Kathy

This has to have been a challenging book to write, to make this information accessible to readers with a range of scientific knowledge and literacy。 For me, a retired physician with dated knowledge of the matters covered, the first third or so was a bit too elementary, while the rest was terrific。 The information is useful for me as a citizen of today, as well as for me as a cancer patient。 I can imagine others for whom the rest would seem overly technical。 I think the book is not quite as succe This has to have been a challenging book to write, to make this information accessible to readers with a range of scientific knowledge and literacy。 For me, a retired physician with dated knowledge of the matters covered, the first third or so was a bit too elementary, while the rest was terrific。 The information is useful for me as a citizen of today, as well as for me as a cancer patient。 I can imagine others for whom the rest would seem overly technical。 I think the book is not quite as successful as the one the author wrote on cancer, but it is close。 。。。more

Delway Burton

Wonderful book in the path of his previous two。 This follows the historical path to present day of the cellular basis of all life and its role in medicine。 He is an excellent writer mixing the dense history of science with clinical cases from his own experiences as a researcher and physician。

Mike Foreman

This book covers Siddhartha's belief that cells are at the core of disease, life and health。 Idea's that he has expounded for years (see his TED talk from 2015) and that makes great sense。 He explains the current medical thinking about how cells work, much of which I found fascinating, such as how the immune system distinguishes self from non self。 Very good explanations of cellular biology that is easy to understand without annoying analogies that you find in other books。If you though his Pulit This book covers Siddhartha's belief that cells are at the core of disease, life and health。 Idea's that he has expounded for years (see his TED talk from 2015) and that makes great sense。 He explains the current medical thinking about how cells work, much of which I found fascinating, such as how the immune system distinguishes self from non self。 Very good explanations of cellular biology that is easy to understand without annoying analogies that you find in other books。If you though his Pulitzer Prize winning book "Emperor of all Maladies" was good, I find this one even better。 I would be shocked if he didn't win the Pulitzer Prize a second time - it is a magnificent book。 。。。more

Stetson

Full Review -> https://stetson。substack。com/p/a-cell。。。The Song of the Cell by Siddhartha Mukherjee is one of the most highly anticipated non-fiction books of 2022。 Mukherjee of Emperor of All Maladies success, is an assistant professor of hematology and oncology at Columbia University's Medical Center。 Mukherjee's CV is astounding, featuring MD/DPhil credentials, 50+ research articles, a Rhodes Scholarship, a Pulitzer prize, and numerous other awards。 It is unfathomable how Dr。 Mukherjee keeps Full Review -> https://stetson。substack。com/p/a-cell。。。The Song of the Cell by Siddhartha Mukherjee is one of the most highly anticipated non-fiction books of 2022。 Mukherjee of Emperor of All Maladies success, is an assistant professor of hematology and oncology at Columbia University's Medical Center。 Mukherjee's CV is astounding, featuring MD/DPhil credentials, 50+ research articles, a Rhodes Scholarship, a Pulitzer prize, and numerous other awards。 It is unfathomable how Dr。 Mukherjee keeps up with all his work on a day-to-day basis。 This breakneck work-pace clearly weighs on him some as Mukherjee often appears fatigued and mildly disheveled in interview。 Nonetheless he is always a model of lucid and intelligent communication。 I have really enjoyed both his prior books, Emperor of All Maladies and The Gene, which are respectively histories of cancer and genetics。 The Song of the Cell completes the trilogy of sorts, presenting an idiosyncratic, special topics history of cellular biology。The Song of the Cell ambitiously recap the foundations of cellular life science。 Mukherjee chooses to start with the invention of microscopy。 The history of science is often a history of what questions technological advancement allows curious people to ask ("highbrow science was born from lowbrow tinkering"), but Mukherjee also makes a compelling case that the conceptual work of scientists was important to the field's advancement not just technology。 The unifying and bold Mukherjee identifies and also uses to organizes his otherwise divided narrative is that cells are "the elementary particles of organisms。" Two critical premises support this conceptual understanding of life。 One, all living organisms are composed of one or more cells。 Two, the cell is the basic unit of structure and organization in organisms。 In other words, Mukherjee is saying "the life of an organism reposes in the life of a cell。" He attributes these foundational concepts of cell biology to two German men, zoologist Theodor Schwann and Botanist Matthias Schleiden who derived it their work and the work of first-mover microscopists, Antonie van Leeuwenhoek and Robert Hooke。From this central idea, a sexpartite of mini-histories spirals forth, touching on a wide range of topics: foundational discoveries in cell biology, cellular development and evolution, the blood as a complex organ of cells, the Covid-19 pandemic, organ systems, and regenerative medicine。 The prose is lucid and vivid, moving readers quickly through the 500 page book。 Mukherjee relies on fewer extended metaphors and verbal flourishes relative to his prior books, but this is an improvement。 The thing that holds the work back is that it doesn't hold together well, especially when couched as a work of science history and communication。 It is admittedly difficult to knit together cellular biology knowledge and related history into a single book。 The field is inherently balkanized and intwined with other disciplines。 There is also just too much content to cram into a single book without losing a lot of the audience。 Mukherjee is still able to hit a lot of important moments but has to sacrifice a lot of depth, especially on the history and human side of the science。 This is what added a value in his other books compared to just reading a textbook or research article, especially for a reader with a background in science (like myself)。The Song of the Cell is still an important work of popular science history。 Mukherjee communicates complex science without oversimplification。 He also shows discipline by not overhyping research findings or groundbreaking topics in the book。 He is largely able to avoid many of the pitfalls of popular science writing。 A lot of curious lay reader will really enjoy and benefit from reading The Song of the Cell。 。。。more

Martin, finally caught Covid

If you don’t have a medical background do not read this book。

Maddy

Another fantastic chunky non-fiction from Mukherjee。 In many ways this feels like a natural follow up to his previous book, The Gene, and I would recommend people read that first。